Similarly, Foxf2 is essential for the proper downregulation of E-cadherin and the regulation of Zeb2 and Id2 during a TGFβ-induced EMT of Py2T murine breast cancer cells that have been derived from a tumor of the MMTV-PyMT mouse model of breast cancer (Additional file 1: Figure S3G). This evidence concerns the gene ZEB2 and breast cancer.