ZEB1 and lung cancer: The mechanism by which Foxf2 regulates the expression of these transcription (co)factors remains elusive, but the presence of putative Foxf2 binding sites in the promoter region of Zeb1 and Zeb2 (data not shown) and data from Kundu et al. [75] in nonsmall-cell lung cancer (NSCLC) cells suggest a direct regulatory mechanism, thus ensuring the downregulation of cell-cell junctions at multiple levels (Fig. 7).