Consistent with the results obtained by using the artificial GFPcODC-transfected cancer cell model system, using the more physiological relevant matrigel stem cell sphere cultural condition (Fig. 5e) and stem cell marker CD44 selection (Fig. 5f, g), we further demonstrated that FL118 exhibited much higher effectiveness in inhibiting sphere and colony formation of pancreatic cancer stem-like cancer cells (Fig. 5e, f and g). Here, CD44 is linked to familial pancreatic carcinoma.