ABCG2 and pancreatic neoplasm: Since ABCG2 is a critical efflux pump that maintains viability of latent stem-like cancer cells [23–29], the capability of FL118 bypassing ABCG2 resistance makes it effective in killing latent, stem-like cancer cell populations and may also overcome the effect of desmoplasia-mediated limitation of drug access to pancreatic tumors.