FGF2 and neoplasm: Cancer-associated fibroblasts (CAFs), the activated form of tissue-resident fibroblasts, can promote tumor angiogenesis by secreting several proangiogenic cytokines, such as vascular endothelial growth factor A (VEGFa), fibroblast growth factor 2 (FGF2) and proteolytic enzymes, such as matrix metalloproteinases (MMPs) [3, 4].