To further explore the role of PTENP1 overexpression and exosomal PTENP1 in bladder cancer in vivo, we injected EJ cells with PTENP1/ NC lentiviral vector or PTENP1/NC Exos derived from 293A cells transfected with PTENP1/ NC lentiviral vector into nude mice. This evidence concerns the gene PTENP1 and urinary bladder carcinoma.