Because the incomplete repair of oxidative DNA damage may contribute to the development of psychotic disorders [1, 17, 18] and because TRAX and many of its interacting proteins (Table 1) are risk genes and/or markers of mental disorders, the present review focuses on the emerging role of TRAX/DISC1 interactome(s) in DNA repair as well as their potential implications in psychiatric disorders. This evidence concerns the gene DISC1 and psychiatric disorder.