The STZ-induced type 1 diabetic rats showed a significant decrease in GSH (4.31 ± 0.150, p ≤ 0.001), SOD (29 ± 0.040, p ≤ 0.01), CAT (0.05 ± 0.006, p ≤ 0.05) and C-peptide levels (0.5 ± 0.220, p ≤ 0.0001) when compared to the normal control group. Here, SOD1 is linked to type 1 diabetes mellitus.