CDH2 and acute lymphoblastic leukemia: The role of N-cadherin in the microenvironmental protection of leukaemic cells to anti-cancer agents was first demonstrated in studies showing that N-cadherin expression was associated with resistance to treatment with a farnesyltransferase inhibitor in the murine lymphoblastic leukaemia cell line, B-1, when grown in co-culture with fibroblasts.