Studies have reported that N-cadherin is expressed on primitive sub-populations of leukaemic cells including patient-derived CD34+ CD38− chronic myeloid leukaemia (CML) cells and CD34+ CD38− CD123+ acute myeloid leukaemia (AML) cells, suggesting that N-cadherin is a marker of LSCs [130, 153, 154]. This evidence concerns the gene CDH2 and acute myeloid leukemia.