Thus, as N-cadherin plays a role in trans-endothelial migration and BM homing of circulating tumour cells in melanoma and MM, in addition to AML [91, 156, 167, 173], treatment with GC-4 may by therapeutically relevant in the context of limiting the metastatic dissemination of tumour cells in these cancers. The gene discussed is CDH2; the disease is neoplasm.