In addition, N-cadherin knock-down in the murine MM cell line 5TGM1 significantly inhibited adhesion to BM endothelial cell monolayers in vitro, although N-cadherin knock-down or GC-4 antibody-mediated blocking of N-cadherin did not affect the trans-endothelial migration capacity of MM PCs in vitro [167, 173]. Here, CDH2 is linked to Miyoshi myopathy.