In contrast to the finding of subclonality in Burkitt lymphoma or DLBCL, cell lines NU-DUL-1 and JM1 contain more than 3 different IGLV rearrangements (Fig. 3c, e.g., in cell line NU-DUL-1, 10,266 reads were detected for the rearrangement IGLV1–40-IGLJ2; 3738 reads for IGLV1–44-IGLJ3; 3005 reads for IGLV4–60-IGLJ3, 2974 reads for IGLVI-70-IGLJ3, 1180 reads for IGLV1–44-IGLJ3 (encoding a different CDR3) and 507 reads for IGLV9–49-IGLJ3), suggesting a potential bi/oligoclonaity of these cell lines and that subclonal rearrangements had likely evolved independently. This evidence concerns the gene IGLL5 and Burkitt lymphoma.