CD8A and cancer: However, in a study of esophageal squamous cell carcinoma, CD8+ TILs and AMC showed a negative correlation, and CD8+ TILs and ALC showed a positive correlation with cancer prognosis, which is not consistent with our findings (AMC r = − 0.29, p <  0.001 ALC r = 0.13, p = 0.056) [43].