Although increased NPSR1 protein levels in plasma were reported in asthma [44] and increased NPSR1 mRNA expression was observed in eosinophils from severe asthmatic patients [45], experiments in an experimental asthma mouse model showed no impact of Npsr1 deletion on airway inflammation or hyper-responsiveness, and the authors suggested that NPSR1 affects the disease through a central nervous system-mediated pathway [46]. The gene discussed is NPSR1; the disease is asthma.