SOX9 and colorectal cancer: We could see that in si-MALAT1 group, the expression of miR-145 was higher and SOX9 was lower than NC group, further verifying the knockdown of MALAT1 inhibited the growth of colorectal cancer in vivo by up-regulating miR-145 and down-regulating SOX9 (Fig. 10d-f, P < 0.01).