Then we investigated the influence on cell proliferation, invasion, migration, cell cycle and apoptosis of colorectal cancer through MALAT1 / miR-145 / SOX9. Better understandings of the role of competing endogenous RNA MALAT1, miR-145 and SOX9 will have translational potential for early diagnosis and may lead to the progress of novel treatment strategy against malignant colorectal tumor. The gene discussed is SOX9; the disease is colorectal cancer.