Then we investigated the influence on cell proliferation, invasion, migration, cell cycle and apoptosis of colorectal cancer through MALAT1 / miR-145 / SOX9. Better understandings of the role of competing endogenous RNA MALAT1, miR-145 and SOX9 will have translational potential for early diagnosis and may lead to the progress of novel treatment strategy against malignant colorectal tumor. This evidence concerns the gene MALAT1 and colorectal cancer.