Additionally, in cardiac hepcidin knock-out, not-binding-hepcidin ferroportin knock-in and IRP1/2 knock-out i.v. iron treatment restored myocardial ID and completely suppressed all morphological changes as well as metabolic and mitochondrial abnormalities, including even these alterations which occurred after myocardial infarction. The gene discussed is ACO1; the disease is myocardial infarction.