Additionally, in cardiac hepcidin knock-out, not-binding-hepcidin ferroportin knock-in and IRP1/2 knock-out i.v. iron treatment restored myocardial ID and completely suppressed all morphological changes as well as metabolic and mitochondrial abnormalities, including even these alterations which occurred after myocardial infarction. Here, SLC40A1 is linked to myocardial infarction.