PAGE5 has also been shown to negatively regulate the expression of apoptotic genes and promote the survival of melanoma cells via suppression of apoptosis.54 The MAGE antigen MAGE2C, which was upregulated in hMSC‐TERT relative to primary hMSC, promotes both cell proliferation and viability of mast cells.55 Recently, CRISPR/Cas9 MAGEC2 knockout melanoma cells have been shown to have increased TNFα‐induced apoptosis.56 Collectively, MAGE genes have been shown to repress p53 transactivation and apoptosis and regulate cell cycle progression (as reviewed in Sang and colleagues57). This evidence concerns the gene TNF and melanoma.