Significantly blunted/absent responses to intermittent PTH are observed when PTH receptors are not present in DMP1‐expressing cells using both Cre deleted strains.26, 28 Canonical PTH receptor signaling via Gsα/cAMP in osteoblast lineage cells is required for iPTH‐induced gains in bone mass.29 In contrast, apparently discordant results are observed with respect to responses to continuous hyperparathyroidism. This evidence concerns the gene PTH and hyperparathyroidism.