DMP1 and hyperparathyroidism: Significantly blunted/absent responses to intermittent PTH are observed when PTH receptors are not present in DMP1‐expressing cells using both Cre deleted strains.26, 28 Canonical PTH receptor signaling via Gsα/cAMP in osteoblast lineage cells is required for iPTH‐induced gains in bone mass.29 In contrast, apparently discordant results are observed with respect to responses to continuous hyperparathyroidism.