PLS3 and osteogenesis imperfecta: Heterozygous Wnt family member 1 (WNT1) mutations have been found in adults with dominant early‐onset osteoporosis and a homozygous mutation causes severe osteogenesis imperfecta.9 Mutations in plastin 3 (PLS3),10 a gene encoding plastin 3, which is involved in actin bundle formation in the cytoskeleton, have been associated with a X‐chromosomal osteoporosis form.