Thus, the present study investigated the effects of T2D on insulin‐stimulated bone blood flow and biomechanical properties by comparison of hyperphagic, diabetic Otsuka Long‐Evans Tokushima Fatty (OLETF; model of hyperphagia‐induced obesity resulting in insulin resistance and T2D24) rats (O‐T2D) with normoglycemic, normal weight, control OLETF rats (O‐CON). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.