Multiple factors including proteins, parathyroid hormone (PTH), phosphate, oxidized lipids, and vitamins D and K are implicated in both bone and vascular metabolism, illustrating the interaction of these two seemingly unrelated conditions.1 Some study has shown that diabetic microvascular complications contribute to risk of fracture.2, 3 For people who do not suffer from diabetes or hypertension with microvascular disease (MVD), the risk for fracture remains elusive. This evidence concerns the gene PTH and diabetes mellitus.