CRH and Cushing syndrome due to macronodular adrenal hyperplasia: In conclusion, our results indicate that the CRH‐Tg mouse model has many features that are similar to that of Cushing's syndrome patients, including loss of trabecular bone volume, trabecular thinning, cortical thinning, and decreased osteoblast and increased osteoclast activity markers at the gene expression and cellular level.