CRH and pituitary gland adenoma: As expected, the spleen weight in CRH‐Tg mice was significantly reduced compared to WT mice, highlighting the immunosuppressive effect of GCs.46 In contrast, the adrenal gland weights were significantly increased in CRH‐Tg mice, which is likely due to chronic ACTH activation because there is no negative feedback regulation of the HPA axis, and is consistent with what is observed in Cushing's disease caused by a pituitary adenoma.47