Unfortunately, an ongoing limitation to therapeutic GC use is the myriad of negative side effects including the development of Cushing's syndrome.2, 3 Cushing's syndrome can result from exogenous administration of GC drugs or it can arise from endogenous over production of cortisol, usually secondary to an adrenocorticotropic hormone (ACTH)‐secreting pituitary tumor. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.