CLIC3 and ovarian neoplasm: Interestingly, in cultured A2780 ovarian carcinoma cells and in pancreatic and ovarian tumors that contain elevated levels of CLIC3, CLIC3 functions to mediate the return of α5β1 from late endosomes/lysosomes to the plasma membrane.20 We hypothesize that CLIC3 may act similarly in osteoblasts to direct the transport of PS to the plasma membrane or to matrix vesicles.