In the Prospective comparison of Angiotensin Receptor-neprilysin inhibitor with Angiotensin converting enzyme inhibitor to Determine Impact on Global Mortality and morbidity in Heart Failure (PARADIGM-HF) study of patients with HFrEF, angioedema was confirmed in 0.45% of patients receiving LCZ696 therapy and 0.24% of patients receiving enalapril therapy (111), a numerical difference that was not statistically significant (P = 0.13). Here, ACE is linked to heart failure.