At a later stage of the infection, the observed transition is associated with high levels of Th2 cytokines, such as IL-4, IL-10, TGF-β, and IL-13, which correlates with disease severity (Ly et al., 2007; Raju et al., 2008; Almeida et al., 2009; Redente et al., 2010). This evidence concerns the gene IL10 and infection.