Consistent with these findings, in the sera of patients during the active phase of visceral leishmaniasis it was detected a significant increase in inflammatory mediators including LTB4, RvD1, PGF2α (PGF2α), IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF-α, and a decreased level of TGF-β1 (Araújo-Santos et al., 2017). This evidence concerns the gene IL6 and visceral leishmaniasis.