An increasing number of studies suggested that PD-L1 is highly expressed in solid tumors, including colorectal cancer (16), lung cancer (17), pancreatic carcinoma (18), hepatocellular carcinoma (19), gastric cancer (20), ovarian cancer (21), endometrial cancer (22, 23), and cervical cancer (24, 25). The gene discussed is CD274; the disease is colorectal cancer.