In this study, Muzumdar et al. showed that KRAS deficiency in pancreatic cancer cells, achieved by inactivation of the gene by means of CRISPR/Cas9 excision, reduced cell growth kinetics in some PDAC cells lines and increased their dependence on phosphoinositide-3-kinase (PI3K) and downstream the mitogen-activated protein kinase (MAPK) activity for proliferation. The gene discussed is KRAS; the disease is pancreatic neoplasm.