Our recent meta-analyses showed significant associations between peripheral blood IL-6, tumor necrosis factor, IL-1β, IL-2, IL-10, C-reactive protein, and RANTES levels and PD (23), and significant higher blood levels of TNF-α, TNFR1, IL-1β, IL-6, IL-8, and VEGF levels in ALS patients when compared with controls (24). The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.