To investigate whether different drugs involved in the management of T2DM, vary in their effects on innate immune function, we compared the broad cytokine production including TNF-α, IL-10, IL-8, IL-6, MCP-1, RANTES, IP-10, and MIG of monocytes purified from T2DM individuals under different drug regimens (see Table 1 for characteristic of individuals). This evidence concerns the gene CXCL8 and type 2 diabetes mellitus.