Another important observation is that macrophage marker CD68+ phenotype density was found to be associated with multiple markers in the tumor including STAT3, ABL1, CDH1, MAK3K1, MAP2K1, MAP2K4, TTK, IKBKB, IL1RAP, NOTCH1, ITGB4, and JAK1. The gene discussed is IL1RAP; the disease is neoplasm.