Another important observation is that macrophage marker CD68+ phenotype density was found to be associated with multiple markers in the tumor including STAT3, ABL1, CDH1, MAK3K1, MAP2K1, MAP2K4, TTK, IKBKB, IL1RAP, NOTCH1, ITGB4, and JAK1. This evidence concerns the gene MAP2K4 and neoplasm.