A notable observation was the significantly higher expression of DNA damage repair pathway genes, in particular those involved in homologous recombination and mismatch repair pathways) in tumor tissues (Figure 2A, e.g., BRCA1, BRCA2, BRIP1, FANCA, FANCG, FANCC, RAD51, XRCC4, MSH2, MSH6, MCM7, MCM4, PCNA). This evidence concerns the gene XRCC4 and neoplasm.