NFKB1 and colitis: In fact, the pharmacological inhibition of MALT1 in dextran sulfate solution (DSS)-induced colitis was found to be protective through the inhibition of NF-κB and NLRP3 inflammasome activation in macrophages (157), and a T cell-dependent transfer model of autoimmune colitis found that Malt1−/− T cells were unable to induce colitis (92).