While CBM-associated mutations are the most directly linked to TCR signaling, other disruptions which can indirectly impact TCR signaling to cause atopic disease include actin cytoskeleton remodeling genes such as dedicator of cytokinesis 8 (DOCK8) deficiency (148), Wiskott-Aldrich Syndrome (WAS) protein interacting protein (WIP) deficiency (149), Wiskott-Aldrich Syndrome (150), actin related protein 2/3 (ARP2/3) complex mutations (151–153) and, potentially, ZAP70 deficiency (154, 155). This evidence concerns the gene DOCK8 and Wiskott-Aldrich syndrome.