INS and diabetes mellitus: To date, standards of medical care in diabetes include such pharmacological groups as secretagogues (sulfonylureas), sensitizers (biguanides, thiazolidinediones), glycosurics (inhibitors of the sodium glucose cotransporter type 2), alpha-glucosidase inhibitors, and peptide analogs (GLP-1 analogs and agonists or DPP-4 inhibitors), as well as human or recombinant insulin (29).