Thus, this study produced results which are consistent with the findings of a great deal of our previous work on the chronic oral administration of ZB-16 to male rats with STZ-NA-induced T2D, demonstrated that ZB-16 exerts a pronounced antidiabetic activity due to the improvement of glucose utilization by stimulating GLP-1 and insulin secretion, as well as protective action on pancreatic β-cells (11). This evidence concerns the gene GCG and type 2 diabetes mellitus.