GRN and status epilepticus: PGRN is playing a role in autoimmune mediated diseases such as rheuma or bowel disease or status epilepticus or in suppression of neuroinflammation (30, 35–37) Recently, EpiphrinA2 as a part of the Ephrin receptor kinase has been identified as functional receptor of PGRN and the potential of PGRN phosphorylating and activating the EpiphrinB2 receptor (38) linking it to the dysfunction in the EpiphrinB2 pathway known in AE mediated by autoantibodies against the NMDA-receptor (39, 40).