It has been reported that LPA is present in abundance in the serum of patients with an acute myocardial infarction (AMI) (Chen et al., 2003), and LPA1 and LPA3 receptor protein levels are increased in the ischemic heart that develops cardiac remodeling, implying that LPA plays a role in cardiac remodeling after a MI. This evidence concerns the gene LPAR1 and myocardial infarction.