ENPP2 and cardiovascular disorder: LPA, as a phospholipid signaling molecule, which is produced from circulating lysophosphatidylcholine (LPC) by ATX, is involved in multiple cardiovascular diseases (Smyth et al., 2014; Chen et al., 2017; Gu et al., 2017; Nsaibia et al., 2017; Shen et al., 2018).