Moreover, in a murine model of myocardial infarction S100A4 KO mice showed more adverse fibrotic remodeling and post-ischemic damage, and this effect was attenuated upon reconstitution of S100A4 protein levels after adeno-associated virus serotype 9 (AAV9)-mediated overexpression of S100A4 (Doroudgar et al., 2016). The gene discussed is S100A4; the disease is myocardial infarction.