The vasoconstrictive and pro-angiogenic properties of NPY have been found to perform compensatory or detrimental myocardial remodeling in response to hemodynamic overload and ischemia (Zukowska-Grojec et al., 1998a; Ghersi et al., 2001; Mcdermott and Bell, 2007). The gene discussed is NPY; the disease is ischemia.