However, as evidence suggests that CGRP possesses protective properties in various cardiovascular diseases (Smillie et al., 2014; Aubdool et al., 2017), there are concerns regarding cardiovascular safety despite minimal cardiovascular issues being observed in clinical trials to date (Paemeleire and MaassenVanDenBrink, 2018; Raffaelli and Reuter, 2018). Here, CALCA is linked to cardiovascular disorder.