In human patients with hypertension, plasma CGRP has been found to be higher (Masuda et al., 1992), unchanged (Schifter et al., 1991), and decreased (Edvinsson et al., 1989; Portaluppi et al., 1992) as reviewed by several groups (including Dong et al., 2002; Smillie and Brain, 2011). The gene discussed is CALCA; the disease is hypertensive disorder.