A few studies have shown that UA has potent of anti-inflammatory, anti-oxidative, anti-cancer, and lifespan-prolonging activities, which inhibit multiple pathways, including ROS, lipopolysaccharide (LPS), and inducible nitric oxide synthase pathways (Bialonska et al., 2009; Ryu et al., 2016; Spigoni et al., 2016; Guada et al., 2017; Boakye et al., 2018; Xu et al., 2018). Here, NOS2 is linked to cancer.