In this study, we aimed to validate the influence of CYP2C19*2, CYP2C19*3, and N6AMT1 rs2254638 on the on-treatment platelet reactivity with clopidogrel therapy by the VASP-phosphorylation assay, and to observed whether polymorphisms in CYP2C19 and N6AMT1 affected clopidogrel response independently in Chinese CAD patients. The gene discussed is CYP2C19; the disease is coronary artery disorder.