We performed a meta-analysis of HSPG2 rs2445142 in TD occurrence including the Syu et al. (2010) discovery sample, Greenbaum et al. (2012) Israeli and selected CATIE samples, and our Canada (European), United States (European), Canada/United States (African American), and IMPACT (European) samples, totaling 324 TD cases and 515 TD-negative controls. Here, HSPG2 is linked to thanatophoric dysplasia.