In a study on 35 chondrosarcoma biopsies (a malignant bone cancer occurring in middle aged patients), ERα (mRNA and IHC) and CYP19A1 (mRNA and activity) were demonstrated in the majority of the samples, and the AI exemestane impaired the E2- and androgen-induced proliferation of primary chondrosarcoma cells (Cleton-Jansen et al., 2005). Here, CYP19A1 is linked to chondrosarcoma.