Similar to the AKR1C3/17βHSD5 data reported earlier, results on SDR5A expression are inconclusive as SRD5A2 was down-regulated in a study on 47 tumor specimens compared with adjacent normal tissue (Sinreih et al., 2013), but both SRD5A1 and SRD5A2 resulted unchanged in another study on 122 tumors (although only five controls were studied) (Tanaka et al., 2015). This evidence concerns the gene SRD5A2 and neoplasm.