This study used CSF tau measures of, on average, late middle-aged MCI individuals (mean age, 61.4) to validate MRI patterns gathered from healthy young (mean age, 22.2), healthy elderly (mean age, 76.7), and mild AD (mean age, 76.6) participants; only volume loss in the medial temporo-parietal network was associated with pathological levels of tau in the MCI patients. This evidence concerns the gene MAPT and Alzheimer disease.