Another study that focused on the proteomic levels of post mortem human brain samples obtained from striatum and cortex identified a significant increase in the level of antioxidant defense proteins, including peroxiredoxins (Prxs) 1, 2 and 6 and Gpx-1 and 6 in individuals with HD (Sorolla et al., 2008). The gene discussed is GPX1; the disease is Huntington disease.