TgCRND8 mice (a mouse model of AD, Table 11) on this diet show reduced DNA methyltransferase activity, hypomethylation of the Psen1 promoter, increased PSEN1 expression, and increased level of amyloid plaques (Fuso et al., 2008; Fuso et al., 2011). This evidence concerns the gene PSEN1 and Alzheimer disease.