Furthermore, NG and nGO effectively decrease the angiogenic potential of a wild-type p53 glioma cell line (U87) by decreasing intracellular ROS and nitric oxide synthesis and leading to the downregulation of NF-κB-dependent proteins IL-6, IL-8, GROα, and MCP-1. The gene discussed is NFKB1; the disease is central nervous system cancer.