EGFR and central nervous system cancer: Previous studies showed that carbon nanoparticles were not only intensively taken up by glioma cells but that they also decreased migration and invasiveness due to impaired extracellular adhesion and EGFR/AKT/mTOR signaling pathway regulation.13 Therefore it was suggested that carbon nanoparticles (i.e., NG and nGO) could influence other basic physiological activities of glioma cells and that the process of blood vessel growth toward the tumor should be assessed.