Taken together, the B16F0 melanoma transplantation model confirmed a role for Vegfr2 gene dosage in regulating the sensitivity to transplanted melanoma tumor growth and tumor associated neovascularization and suggests that loss of endothelial FGFR1/2 signaling does not further enhance the effect of reduced VEGFR2 expression. Here, FGFR1 is linked to melanoma.