APP and Alzheimer disease: Considering the higher number of DEGs observed in APP/PSEN1 mice (181 versus WT mice) compared with the 14 DEGs observed in MAPTP301S mice (versus WT mice, FDR ≤ 0.1 in this article versus 0.05 in Haure-Mirande et al. [53]) and considering that the complement system is one of the top pathways disturbed in APP/PSEN1 mice but not MAPTP301S mice, one possible conclusion is that the amyloidogenic context is the key feature of AD that underlies the complement system perturbation.