In this regard, it is important to note that C1q is part of the complement subnetwork driven by TYROBP [2], but importantly, reversal of the subnetwork was not detectable by RNA-seq as performed in this study of tauopathy, a result that is different from our observations in APP/PSEN1 mice deficient for TYROBP [53]. This evidence concerns the gene TYROBP and tauopathy.