TYROBP and early-onset autosomal dominant Alzheimer disease: TYROBP (tyrosine motif binding protein, aka DAP12, DNAX-binding protein-12) has been identified as a causal regulator of multiple genes involved in microglia phagocytosis, and its expression is increased in the brains of patients with Alzheimer’s disease (AD) and mouse models of cerebral amyloidosis [1, 2].