APP and Alzheimer disease: Moreover, immunohistochemistry and western blot analysis of pan-neurons differentiated from human iPS cells in which the APP gene was mutated (APP KM670/671NL) by genome editing also supported the reduction of SRRM2 and PQBP1 together with the increase of pSer1068-SRRM2 in human AD neurons (Fig. 3i, j).