Therefore, to investigate the relationship between intracellular Aβ and SRRM2 phosphorylation at Ser1068, we next performed double staining of brains from 5xFAD mice, APP-KI mice (AppNL-G-F/NL-G-F) and human AD patients carrying a PS1 mutation (Met146Leu). The gene discussed is SRRM2; the disease is Alzheimer disease.