The increase of pSer1068-SRRM2 in cortical neurons of 5xFAD mice, APP-KI mice and human PS1-linked AD patients was not directly related to extracellular Aβ aggregates (i.e., the distance from extracellular Aβ aggregates did not determine the level of pSer1068-SRRM2 in neurons) (Supplementary Fig. 14). Here, APP is linked to Alzheimer disease.