First, F98 is carcinogen (nitrosourea-mediated mutagenesis) induced rat glioblastoma model that might differ not only with respect to the molecular characteristics affecting radiosensistivity (e.g., presence of BRCA1 mutation) but also tumor invasion and angiogenesis pattern from the human glioblastoma in patients40,41. The gene discussed is BRCA1; the disease is glioblastoma.