The resultant model could separate those with VAP (R2 0.73, Q2 0.67, p = 0.002, AUROC 0.98 (0.92–1.00)) and contained 5,6-DHET, 8,9-DHET, IL-6, IL-8, ICAM-1, platelet count, CRP and PaO2:FiO2 ratio with 5,6-DHET and platelet count being most important in the model. Here, IL6 is linked to ventilator-associated pneumonia.