As one can imagine, this is one of the broad spectrum of coverage of ALS patients, and given the heterogeneity of the disease, it is remarkable that Betz cells of all patients investigated displayed similar cellular pathologies of increased protein expression as in the case of ZFYVE27, PPARG, and PPARGCA1, decreased expression of YWHAZ, and accumulation of ZFYVE27 within the cytoplasm. This evidence concerns the gene ZFYVE27 and amyotrophic lateral sclerosis.