However, PPARG expression was prominently increased in the Betz cells of both sALS patients and ALS patients with TDP43 pathology (average percentage of Betz cells with increased PPARG expression: control: 22 ± 3; sALS: 83 ± 5; TDP43: 74 ± 12). Here, TARDBP is linked to amyotrophic lateral sclerosis.