There is, however, very good evidence that this is not the case31; (2) The conversion of Chol to CE (the LCAT-catalyzed reaction, without involving a decrease in LCAT concentration) could be less efficient in the plasma of patients with atherosclerosis; (3) The Chol efflux from peripheral tissues to HDL, and therefore the concentration of Chol in the plasma, could be negatively correlated with the amount of atherosclerosis32,33. Here, LCAT is linked to atherosclerosis.