Additionally, pharmacological induction of ER stress upregulates the lectin-type oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) in neutrophils and induces transformation of neutrophils into immunosuppressive cells [241,242], suggesting that the IRE1/XBP1 axis controls tumor-associated myeloid cells. Here, ERN1 is linked to neoplasm.